Endocrine Abstracts

The study investigated the potential alteration in the level of insulin and adiponectin, as well as the expression of INSR and GLUT-4 in chronic restraint stress rats. Sprague–Dawley rats were randomly divided into two groups: the control group and stress group in which the rats were exposed to one of the four different restraint stressors; 1 h, twice daily for a period of 7 days (S7D), 14 days (S14D) and 28 days (S28D). To minimize habituation, the sequence of the stress...

Virtually all biochemical processes in the body require dietary micro-nutrients and imbalance in any of these essential of the diet have the potential to impair metabolic activities. Deficiencies of several mineral nutrients result in stunting, down-regulated immune responsiveness and altered metabolic activities. Appropriate dietary intake of these mineral nutrients can address this deficiency and is currently recommended as part of a lifestyle intervention for the prevention...

The female reproductive system provides several functions. These include ovulation, pregnancy and childbirth. The incidence of diabetes mellitus (DM) is increasing rapidly worldwide and it is associated with reproductive complications. Metformin is an oral hypoglycaemic drug used in the management of DM. The present study determined the effect of metformin on some reproductive function in alloxan-induced diabetic female Sprague-Dawley rats.<p class="abst...

The female reproductive system provides several functions. These include ovulation, pregnancy and childbirth. The incidence of diabetes mellitus (DM) is increasing rapidly worldwide and it is associated with reproductive complications. Metformin is an oral hypoglycaemic drug used in the management of DM. The present study determined the effect of metformin on some reproductive function in alloxan-induced diabetic female Sprague-Dawley rats.<p class="abst...

A growing number of studies have reported beneficial health effects of cocoa and turmeric, including atherosclerosis, hypertension and insulin resistance. Relatively few studies have investigated the preventive or therapeutic effects of cocoa and turmeric against obesity-related metabolic disorders and co-pathologies. The study was undertaken to determine the effects of cocoa and turmeric powder supplementation on glucose tolerance, insulin sensitivity and lipid profile in rat...

We examined the effect of dietary niacin supplementation on fat mass, glucose control, insulin sensitivity, lipid profile, and adiponectin level in diet-induced obese rats. Twenty-one male Sprague-Dawley rats (n=21) were initially divided into two (2) groups of seven and fourteen rats; the group of 14 rats was fed with a high-fat-diet (HFD) and the other group of 7 rats consumed the control diet. Eight weeks after the diet regimen started, half of the rats from the HFD group w...

Several epidemiological evidences indicate that consumption of coffee is associated with a lower risk of type 2 diabetes mellitus (T2DM); however, there is dearth of experimental data to support these observations. Given that associations do not necessarily infer causality; the present study investigate the effect of coffee consumption on glucose regulation, T2DM and the probable mechanisms of action, if any, using an animal model. Twenty-four (24) Sprague–Dawley rats wei...

The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is however limited information on the specific neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual be...

The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is however limited information on the specific neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual be...